Tuesday, April 30, 2013

Obama says his health care law mostly in place

WASHINGTON (AP) ? President Barack Obama argues that his signature health care law is already benefiting most Americans even if they don't know it.

The president says despite what he calls "sky is falling" predictions, the Affordable Care Act's provisions are already in place for those with health insurance.

He says what's left is to help those Americans who don't have health care coverage to obtain it. He acknowledged that is "a big undertaking" and predicted there could still be some glitches as the details are worked out.

Obama was speaking at a news conference Tuesday at the White House.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-30-Obama-Health%20Care/id-eb511e97107b444286f12cbb183676ca

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Comet of the century? ISON has 'potential' to be visible all day.

As sun-grazing comet ISON approaches the sun, it's getting progressively brighter ? and might even flare into a dazzling object bright enough to be visible in broad daylight.

By Joe Rao / April 25, 2013

Comet ISON was photographed by the Hubble telescope on April 10, 2013 when the comet was 386 million miles from the Sun (slightly closer than Jupiter's orbit). Around the time the 'comet of the century' makes its closest approach to the Sun, on November 28, it may briefly become brighter than the full Moon, say NASA researchers.

NASA Hubble telescope / Courtesy of NASA / Reuters

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An exceptional comet flying ever closer to the sun may offer an amazing naked eye sight to Earth dwellers this fall as it gradually brightens.

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As comet C/2012 S1 (ISON) continues to approach the sun, it is slowly responding to the increasing warmth of the sun and getting progressively brighter. The comet is getting considerable scrutiny from both amateur and professional scientists because it's a rare sungrazing comet, destined to approach to within 730,000 miles (1.17 million kilometers) of the surface of the sun on Nov. 28. Because of this extremely close approach, comet ISON holds the "potential" to flare into a dazzling object ? possibly becoming bright enough to be briefly glimpsed in broad daylight.?

Still, at this early stage in the comet's development, we can't be sure if this will actually happen.

A Swift look

Although still quite far from the sun and very faint, the comet has been imaged by two orbiting observatories. Astronomers from the University of Maryland at College Park and Lowell Observatory used NASA's Swift satellite to check out the comet during January and February. Using images acquired from Swift's Ultraviolet/Optical Telescope, the team was able to make initial estimates of the comet's water and dust production and then used these values to determine the size of ISON's icy nucleus.
?These observations revealed that each minute ISON was shedding about 56 tons (51,000 kg) of dust, or about two-thirds the mass of an unfueled space shuttle. Jets powered by sublimating ice also release dust, which reflects sunlight and brightens the comet.

By contrast, however, the comet was producing only about 130 pounds (60 kg) of water every minute, or about four times the amount flowing out of a residential sprinkler system. At the time, however, the comet was nearly half a billion miles from the sun. Typically, a comet's water content remains frozen until it comes within about three times Earth's distance to the sun ? about 280 million miles (450 million km) away. ISON won't be this close to the sun until early July at which time the water production rate should markedly increase.

The water and dust production rates from Swift were used to estimate the size of ISON's icy body. Comparing the amount of gas needed for a normal comet to blow off dust at the rate observed for ISON, the scientists estimate that the nucleus is roughly 3 miles (5 km) across, a typical size for a comet. This assumes that only the fraction of the surface most directly exposed to the sun, about 10 percent of the total, is actively producing jets.

Hubble's turn

More recently, Planetary Science Institute research scientist Jian-Yang Li led a team that imaged comet ISON with the Hubble Space Telescope on April 10 using the Wide Field Camera 3. At this point, the comet was slightly closer than Jupiter at 386 million miles (621 million kilometers) from the sun and 394 million miles (634 million kilometers) from Earth.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/PZCG5RmJADU/Comet-of-the-century-ISON-has-potential-to-be-visible-all-day

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Monday, April 29, 2013

How does pregnancy reduce breast cancer risk?

Apr. 28, 2013 ? Being pregnant while young is known to protect a women against breast cancer. But why? Research in BioMed Central's open access journal Breast Cancer Research finds that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.

Early pregnancy is protective against breast cancer in humans and in rodents. In humans having a child before the age of 20 decreases risk of breast cancer by half. Using microarray analysis researchers from Basel discovered that genes involved in the immune system and differentiation were up-regulated after pregnancy while the activity of genes coding for growth factors was reduced.

The activity of one particular gene Wnt4 was also down-regulated after pregnancy. The protein from this gene (Wnt4) is a feminising protein -- absence of this protein propels a fetus towards developing as a boy. Wnt and Notch are opposing components of a system which controls cellular fate within an organism and when the team looked at Notch they found that genes regulated by notch were up-regulated, Notch-stimulating proteins up-regulated and Notch-inhibiting proteins down-regulated.

Wnt/Notch signalling ratio was permanently altered in the basal stem/progenitor cells of mammary tissue of mice by pregnancy. Mohamed Bentires-Alj from the Friedrich Miescher Institute for Biomedical Research, who led this study explained, "The down-regulation of Wnt is the opposite of that seen in many cancers, and this tightened control of Wnt/Notch after pregnancy may be preventing the runaway growth present in cancer."

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The above story is reprinted from materials provided by BioMed Central.

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Journal Reference:

  1. Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen and Mohamed Bentires-Alj. Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium. Breast Cancer Research, 2013 (in press) [link]

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/M01wkIKwjeM/130428230427.htm

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2 police shot outside Italian premier's office

ROME (AP) ? An unemployed Italian gunman shot and seriously wounded two policemen Sunday in a square outside the premier's office in Rome just as Italy's new government was being sworn in elsewhere in the city, the interior minister said.

Shots rang out in Chigi Square near a busy shopping and strolling area shortly after 11:30 a.m. just as Premier Enrico Letta and his new ministers were taking their oaths at the Quirinal presidential office, about a kilometer (half-mile) away.

The suspected gunman, dressed in a dark business suit, was immediately grabbed by other police in the square, wrestled to the ground and taken away.

The shooting "was the tragic gesture of an unemployed man," Interior Minister Angelino Alfano told reporters after briefing Letta and his new Cabinet about the attack.

A woman passing by during the shooting was also slightly injured, Rome's mayor said. It was unclear if she was grazed by a bullet or hurt in the panic sparked by the gunfire.

It was not immediately clear if the shooting outside the Chigi Palace, which houses the premier's office and other government offices, was timed to coincide with the swearing-in ceremony. But tensions have been running high in Italy following inconclusive elections in February that left the country mired in political deadlock amid a deep recession.

The 46-year-old Letta nailed down a coalition deal only a day ago between two bitter political enemies ? his center-left forces and the conservative bloc of ex-Premier Silvio Berlusconi.

Reporters inside the Chigi Palace press office heard the shots and raced outside. An AP television producer saw the two wounded Carabinieri officers in the square outside the palace. One of them lay on the pavement with blood pouring out of his neck.

Alfano said the alleged gunman ? 49-year-old Luigi Preiti ? wanted to kill himself after the shooting but ran out of bullets. He said six shots were fired.

Security was immediately stepped up near key venues in the Italian capital, but Alfano said authorities were not worried about related attacks.

"The general situation of public order is not causing any worry," he said. "Our initial investigation indicates the incident is due to an isolated gesture, although further investigations are being carried out."

Doctors at Rome's Umberto I Polyclinic said the more seriously injured of the two police officers was a 50-year-old brigadier. They told reporters that a bullet had entered the right side of the officer's neck, damaged his spinal column and was lodged near his shoulder.

The doctors said it wasn't yet known if the spinal column injury had caused any paralysis.

The other victim was a 30-year-old officer who was shot in the leg and had suffered a fracture, hospital officials said.

Preiti was taken to another Rome hospital. News reports said a protective collar was seen around the man's neck.

Italian media reports said the assailant was from southern Calabria and had lived for several years in northern Italy before moving back to Calabria after his marriage fell apart.

Sky TG24 TV quoted the man's brother as saying the alleged attacker had lost his job in a construction firm and was upset over marital problems.

An aide to Foreign Minister Emma Bonino told reporters at the presidential palace that the new Cabinet members were kept briefly inside for security reasons until it was clear there was no immediate danger.

The shooting sparked ugly memories of the 1970s and 1980s in Italy, when domestic terrorism plagued the country during a time of high political tensions between right-wing and left-wing blocs.

The new Cabinet ministers were seen smiling in a group photo as news of the shooting broke and it was apparent they weren't immediately aware of the attack.

"The news arrived after the swearing-in," said Dario Franceschini, one of the new ministers. "Premier Letta is following the situation."

Metal fencing closes off Chigi Square, which flanks Via del Corso, one of Rome's most popular streets with strollers. The public can cross the square by showing identification, and sometimes people can cross it without being stopped. It was unclear if the assailant had asked permission to enter the square.

Rome was jammed Sunday with tourists and residents enjoying a warm sunny morning on the last day of a four-day weekend.

Source: http://news.yahoo.com/2-police-shot-outside-italian-premiers-office-115304512.html

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Kenya's March tea output rises 87 pct yr/yr, exports edge up

NAIROBI (Reuters) - Kenya's tea production in March jumped 87 percent on a year ago to 33.3 million kg due to favourable weather, according to national regulator, the Tea Board.

Kenya, east Africa's largest economy, is the world's top exporter of black tea, which is a major source of foreign exchange, earning it 112 billion shillings last year.

Tea exports last month also inched up to 36.1 million kg from 35.4 million kg in March 2012 on higher supply, the Tea Board said in a statement issued on Friday.

"Higher production was largely attributed to scattered light rainfall conditions experienced in tea growing areas during the second half of the month owing to the gradual onset of the March-May 'long rainfall' season as opposed to severe hot and dry weather conditions experienced in March last year," Sicily Kariuki, the board's managing director said in a report.

Kariuki added that higher export volume was the main reason for an increase in exports.

During the month 24.4 million of tea was sold through the country's weekly auction at the port of Mombasa, a rise from 19.1 million kg in the same period of 2012.

The average tea auction price fell to $2.81 per kg from $3.03 in the same period a year ago.

"Marginal drop in prices was due to anticipation of supply increase owing to the onset of the 'long rainfall' season," Kariuki said.

Pakistan was the biggest buyer of Kenyan tea in March, at 22 percent of total exports.

The country's top five export destinations in March, which account for 75 percent of Kenyan tea exports, were Pakistan, Egypt, Afghanistan, UK and Sudan.

Source: http://news.yahoo.com/kenyas-march-tea-output-rises-87-pct-yr-130129142.html

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Sunday, April 28, 2013

Breffo Spiderpodium review

The Spiderpodium?from Breffo is, um, well… it’s this spider-shaped thing you can use to hold smartphone-sized objects in a variety of ways. It comes in black, blue, graphite (the review unit color), green, pink, purple, or white. ?Let’s give it a look. So where were the spiders?   Inside the box is the Spiderpodium in [...]

Source: http://the-gadgeteer.com/2013/04/28/breffo-spiderpodium-review/

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In Ala., GOP dictates new landscape for education

MONTGOMERY, Ala. (AP) ? Self-declared education reformers have had considerable success across the country over the past few decades, from charter school expansion and private school tuition vouchers to new limits on teachers' job protections. But perhaps nowhere have the triumphs marked a bigger political upheaval than in Alabama, where the new Republican supermajority is dominating the state teachers' organization that was long the epicenter of power.

Alabama Education Association chief Henry Mabry accuses Republicans of hurting public schools with changes to teacher tenure, tax breaks for private school tuition, and limits on AEA collecting dues through the state payroll system.

"There seems to be an unspoken agenda to change the public education system to where it's not even recognizable," Mabry said. He called it "right out of the playbook" of a national movement to eviscerate government in favor of private and for-profit enterprises.

GOP leaders frame their efforts as improving a broken system more concerned with public employees than with children. "It's not that we're punitive toward AEA," House Speaker Mike Hubbard said. "We're just doing the right thing by the taxpayers, and they don't like that."

Alabama's statehouse dynamic has turned on its head since Republicans won legislative supermajorities in 2010, giving them legislative control for the first time since Reconstruction. Soon after, longtime AEA leader Paul Hubbert, who spent more than four decades amassing a reputation as the state's most powerful lobbyist, retired and gave way to Mabry.

"For so long, AEA controlled everything, and they don't anymore," Hubbard said. "They're having a really hard time adjusting to that."

Hubbert, who still lives in Montgomery, said AEA was a predictable target for Republicans because it "had primarily supported Democrats."

The Alabama legislative battles haven't produced the kind of protests seen in Wisconsin after Republican Gov. Scott Walker gutted his state's public unions, but they underscore how quickly public policy can turn after watershed elections. They've also had considerable political ripple effects. The state Democratic Party, once dependent on AEA's organizational muscle, is reeling. Republicans must deal with the realities of a supermajority: Old two-party battles are sometimes reprised as internal party struggles. Both sides say those issues will figure prominently in the 2014 elections.

Immediately, the new GOP Legislature tried to block AEA from collecting money from its 100,000 or so members through the automatic deductions in the state payroll system. The law remains tied up in court, but it would change how AEA collects money, potentially cutting into the estimated $7 million to $8 million that Mabry says it spends each election cycle.

Republicans made it easier to fire teachers and blocked them from being paid during appeals. The party also wants the state to provide liability insurance for teachers ? a key benefit teachers get from AEA. The state already provides similar insurance for non-education employees.

The biggest GOP victory came earlier this year when legislators passed the Alabama Accountability Act with provisions championed by school-choice advocates, including a private-school tuition voucher program for students from low-income households and tax breaks for private school tuition paid by families zoned for poorly performing public schools.

Those ideas have been implemented elsewhere. The tuition scholarship-voucher fund is modeled after a program Jeb Bush enacted as governor of Florida. Other provisions closely track model legislation offered by the American Legislative Exchanges Council, a consortium of conservative state legislators backed mostly by corporate contributions.

Mabry calls the tuition grants and tax breaks "once-in-a-lifetime goodies" for private schools and many parents who already send their children to them. Republicans estimate that the tax credits will divert about $50 million from public school appropriations, but AEA says the number will be much higher. Mabry blasts Hubbard's argument that supporting public schools is different from backing public school employees.

Hubbard spent more than a decade in the minority protesting Hubbert's influence. Hubbard and Senate GOP leader Del Marsh both refer to AEA as "the union," though AEA doesn't have collective bargaining rights and cannot strike. Statehouse lore holds that Hubbert could sit in the gallery and determine the outcome of budget amendments by showing lawmakers a thumbs-up or thumbs-down ? though Hubbert disputes the account.

AEA was an unquestioned success in an otherwise unfriendly state for organized labor. National teachers' union officials recognize it as among the most influential state associations without collective bargaining power. Unlike several other Southern states that have multiple groups, AEA is the product of an integration-era merger of a white group and black group. Hubbert ran AEA for decades with Joe Reed, who is black, as his top deputy.

Both men were longtime executive officers of the state Democratic Party. Hubbert won the Democratic nomination for governor in 1990 but lost the general election. AEA usually took the lead on recruiting candidates, often choosing education employees and administrators. Republicans lambasted the "double dipping" because the officeholders got two state paychecks, and some AEA-backed Democrats were convicted of fraud after a federal investigation found they got paychecks and contracts from state two-year colleges without doing the work.

An enduring example of AEA's old power is the fact that Alabama passes two budgets annually: one for education and the General Fund budget for everything else. Earmarks direct the overwhelming majority of state tax revenues to the education budget. In a state where anti-tax sentiment has always been strong, AEA saw to it that public schools ? and their employees ? got most of the pie.

Hubbert and Mabry say that's the way the electorate wants it. They attribute Republicans' 2010 sweep to a national election centered on President Barack Obama and the economy, not on GOP education policy.

AEA has begun recruiting candidates for 2014 on both sides of the aisle, Mabry said. New district lines give Republicans a decided advantage, particularly in the few remaining district represented by white Democrats. Mabry argued that Republican voters are sympathetic to AEA's positions, particularly on vouchers and tax credits. He noted that some Republicans in Indiana and Ohio were ousted in 2012 after a similar approach.

Hubbard and Marsh said they can win the "school choice" argument on merit. Hubbard's old nemesis, meanwhile, gives him reason not to worry anytime soon. The bottom line, according to Hubbert, is that AEA's philosophy and Republican priorities don't match. "AEA will change with the times, I'm sure," Hubbert said. "But will it be a major player inside the Republican Party? I doubt it."

Source: http://news.yahoo.com/ala-gop-dictates-landscape-education-153449845.html

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Saturday, April 27, 2013

President says Libya harbors Chadian mercenaries

N'DJAMENA (Reuters) - Chad's President Idriss Deby on Saturday that Chadian mercenaries had set up a training camp in neighboring Libya from where they could seek to destabilize his country, an accusation Libyan authorities denied.

Deby said during a radio interview that the mercenaries were free to roam around the eastern Libyan city of Benghazi, hundreds of kilometers (miles) north of the Chadian border.

"I do not want the new Libya to serve as the source of any plot to destabilize Chad," Deby said. "I am asking Libyan authorities to take steps to ensure that Chad does not fall prey to another Libyan misadventure."

But Saleh Gaouda, deputy president of the National Security Committee in Libya's General National Congress who also represents Benghazi, denied any such camps existed.

"Libya ... does not permit military camps where foreigners can find shelter, and will not interfere in the internal politics of our neighbors," Saleh said.

"As a deputy for the city of Benghazi, I can say categorically that there are no such camps in the city."

Chad has had rocky relations with its northern neighbor, going to war with Libya in the 1970s and 1980s when former Libyan leader Muammar Gaddafi tried to seize the Aouzou Strip.

Ties improved after Deby, backed by Gaddafi, seized power in a 1990 military coup. Deby condemned NATO strikes against Gaddafi and was one of the last leaders in region to recognize the new Libyan authorities.

The former French colony of Chad, one of the poorest countries in the world, has been hit by humanitarian crises over the last decade exacerbated by rebellions in the east and south, drought in the arid Sahel region, and flooding.

In March, the Chadian rebel coalition UFR, who lay down their weapons in 2010, warned that they would take up arms again against Deby after he failed to enter talks with them after they agreed to stop fighting.

Chad has sent some 2,000 soldiers to fight alongside French troops to drive Islamists from remote northern towns, mountains and deserts regions of northern Mali.

(Reporting by Madjiasra Nako in N'Djamena and Ghaith Shennib in Benghazi; Writing by Bate Felix; editing by Mike Collett-White)

Source: http://news.yahoo.com/president-says-libya-harbors-chadian-mercenaries-162528582.html

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Friday, April 26, 2013

Samsung extends ATIV branding to all Windows PCs, adds Book 5, Book 6 and SideSync software to the roster

Samsung extends ATIV branding to all Windows PCs, adds Book 5, Book 6 laptops and SideSync software to the roster

Samsung's ATIV branding might not yet be a household name, but that could very well change, as the company has just announced a new naming scheme that places all of its Windows PCs under the ATIV umbrella. As you may recall, the ATIV scheme was previously reserved for convertibles, but under the new structure, even Samsung's existing PC lineup -- we're looking at you, Series laptops -- will retroactively take on the new scheme. The news doesn't stop there, however, as Samsung has also announced two new ATIV Book models and a nifty bit of software known as SideSync to the mix. Read on for the details.

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Source: Samsung

Source: http://www.engadget.com/2013/04/25/samsung-ativ-pcs/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Jake Johnson Imitates Internet Memes, Makes a Quality Grumpy Cat

Source: http://www.thehollywoodgossip.com/2013/04/jake-johnson-imitates-internet-memes-makes-a-quality-grumpy-cat/

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Samsung profit at record high on smartphone boost

Visitors operate Samsung Electronics' Galaxy S4 smartphones at a showroom of its headquarters in Seoul, South Korea, Friday, April 26, 2013. Samsung Electronics Co. said Friday its first-quarter net income jumped to a record high because sales growth in smartphones continued even before the launch of the Galaxy S4 during a typically slow season for the electronics market. (AP Photo/Ahn Young-joon)

Visitors operate Samsung Electronics' Galaxy S4 smartphones at a showroom of its headquarters in Seoul, South Korea, Friday, April 26, 2013. Samsung Electronics Co. said Friday its first-quarter net income jumped to a record high because sales growth in smartphones continued even before the launch of the Galaxy S4 during a typically slow season for the electronics market. (AP Photo/Ahn Young-joon)

Banners advertising Samsung Electronics' Galaxy S4 smartphones are displayed at a showroom of its headquarters in Seoul, South Korea, Friday, April 26, 2013. Samsung Electronics Co. said Friday its first-quarter net income jumped to a record high because sales growth in smartphones continued even before the launch of the Galaxy S4 during a typically slow season for the electronics market. (AP Photo/Ahn Young-joon)

(AP) ? Samsung Electronics Co. said Friday its first quarter profit jumped to a record high as smartphone sales remained strong despite the April launch of an updated version of its flagship Galaxy phone.

Sales of consumer electronics usually slow in the first three months of the year after the holiday shopping season, an effect that analysts thought would be compounded by this month's release of the Galaxy S4 smartphone since many delay buying until the newest model is available. Apple Inc. has cited the upcoming release of a new iPhone as a reason for a slowdown in sales of older models.

Samsung began sales of the S4 in its home South Korean market Friday and starts U.S. sales on Saturday. Analysts expect Samsung's profits to reach new highs in the second and third quarters if S4 sales are strong. Lee Don-Joo, head of sales and marketing at Samsung's mobile division, said sales of the S4 will outdo its predecessor, the Galaxy S III.

Samsung said January-March net profit surged 42 percent to 7.2 trillion won ($6.5 billion) from 5 trillion won a year earlier. That increase was despite booking a one-time charge against earnings related to settlement of its intellectual property battle with Apple. Analysts estimated the charge at $600 million.

Sales rose 17 percent to 52.9 trillion won. Operating profit was up 54 percent to 8.8 trillion won, in line with its preliminary results released earlier this month.

Profit was up 2 percent from the previous quarter's result, beating market expectations for a fall. Sales of the S III smartphone and the oversized handset called the Galaxy Note remained strong and shored up profit, Samsung said. It also spent less on marketing its mobile devices than it did in the previous quarter when competition heated up.

Samsung's IT and Mobile Communications division that makes smartphones, tablets, PCs and cameras reported 6.51 trillion won in operating income for the first quarter, up 56 percent from a year earlier and its highest since Samsung reorganized the division to merge PC and handset departments.

Samsung capitalized on global demand for smartphones with a range of mobile devices that come in a variety of screen sizes and prices, outpacing rivals including Apple Inc. and Nokia Corp.

As the S4 goes on sales several months before rival Apple introduces a new version of iPhone, analysts said Samsung's streak of record-setting profit will not stop any time soon.

"You can say it is like a snowball is rolling," said James Song, head of technology at Daewoo Securities. Song forecast Samsung's second quarter operating income to surpass 10 trillion won ($9 billion).

Market research firm IDC estimated that Samsung shipped 70.7 million smartphones during the first quarter, up 61 percent over a year earlier and capturing 33 percent market share. Apple, the second-largest smartphone maker, sold 37.4 million iPhones. Its market share fell to 17 percent from 23 percent a year earlier, IDC said.

Samsung, based in Suwon, South Korea, is also the world's largest maker of memory chips, televisions, mobile handsets and liquid crystal display panels.

The company's strong performance in the mobile market helped offset sluggish demand for TVs and a still weak recovery in display panel sales.

For the first time in recent years, Samsung refrained from increasing its annual capital expenditure on semiconductor and display panel production lines, a sign that it sees slower growth in demand for memory chips and display panels. Its annual capital expenditure for 2013 will be capped at 22.9 trillion won ($20.5 billion).

But Samsung said it will boost its spending on research and development even though it is already one of the largest R&D spenders. Its R&D expense was $2.97 billion during the first three months of this year, nearly three times more than Apple's $1.12 billion, according to financial information provider FactSet.

"Although market uncertainties from the European crisis and the slow global economic recovery are still lingering, we expect to increase R&D spending for strengthening our competitiveness ahead of planned new product launches," said Robert Yi, head of investor relations at Samsung.

Seo Won-seok, an analyst at Korea Investment & Securities, said Samsung's businesses require heavy spending on research and development for future products, especially divisions that make electronic components.

At a Las Vegas trade show in January, Samsung showcased mobile handsets that use curved glasses, a first stage in what would eventually become flexible displays. Adopting more advanced technology is also crucial to lowering memory chip manufacturing costs.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-04-26-AS-SKorea-Earns-Samsung-Electronics/id-a53caee6645d402895718e62c4d65f4f

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Choosing to Be a Human Reference Standard for HGP - FORA.tv

Bio

Misha Angrist

Misha Angrist is Assistant Professor of the Practice at the Duke University Institute for Genome Sciences & Policy. He holds a PhD degree in Genetics from Case Western Reserve University, an MFA in Writing and Literature from the Bennington Writing Seminars, and was formerly a board-eligible genetic counselor. He has covered the biotechnology industry as market-research analyst and worked as an independent life sciences consultant, writer and editor.

In April 2007 he became the fourth subject in Harvard geneticist George Church's Personal Genome Project and in 2009 had his full genome sequenced at Duke. His book, Here is a Human Being: At the Dawn of Personal Genomics, will be published in the fall by Harper Collins.

Dorit Berlin

Dorit S. Berlin, Ph.D., is principal investigator of the NIGMS Human Genetic Cell Repository, a large biobank funded by the National Institute of General Medical Sciences that focuses on heritable disorders and houses more than 11,000 cell line and nucleic acid samples at the Coriell Institute for Medical Research. Dorit is also principal investigator of the Congenital Heart Disease Genetic Network Study Biorepository, which is funded through the National Heart, Lung, and Blood Institute. Prior to joining Coriell, Dorit was a postdoctoral scholar at Stanford University, where she worked on scientific curation for the Pharmacogenomics Knowledge Base. Dorit also founded and led an education project to create a web-based pharmacogenomics teaching module and implement it as an online exhibit for the Tech Museum of Innovation in San Jose, CA. Dorit earned her undergraduate degree in chemistry from the Massachusetts Institute of Technology and her doctorate in molecular and cell biology from the University of California, Berkeley.

Robert Krulwich

Robert Krulwich covers science for National Public Radio and is Co-host of NPR's "Radiolab." His specialty is explaining complex subjects?science, technology, economics ? in a style that is clear, compelling and entertaining. For several decades he was a correspondent at ABC and CBS News plus he hosted PBS? Frontline, Nova Science Now and a BBC cultural show, "The Edge." TV Guide called him "the most inventive network reporter in television." He has explored the structure of DNA with a banana, created his own Italian Opera "Ratto Interesso" to explain how the Federal Reserve regulates interest rates, he pioneered the use of new animation on ABC's Nightline, World News, and on NPR's Internet site to explore cellular biology and subprime lending.

Marc Salit

Marc Salit is leading a group at the National Institute of Standards and Technology (NIST) dedicated to technology development and measurement infrastructure (standards, reference data, predictive models) for massively multiplexed genome-scale measurement methods. This "Multiplexed Biomolecular Science" group is a multidisciplinary team growing out of work to address microarray measurement science issues, and a long-running effort in technology and measurement science in microfluidics. Marc has worked extensively in measurement science in chemistry and physics, with emphasis on precision measurements, lab automation, algorithm development, measurement uncertainty, traceability, and standards development. His research is now focused on bringing experience from the chemical metrology community to the emerging biometrology community.

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Source: http://fora.tv/2013/04/25/Choosing_to_Be_a_Human_Reference_Standard_for_HGP

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Workers pinned in Bangladesh rubble cry for rescue

In this image taken from AP video, garment worker Mohammad Altab moans to rescuers for help while trapped between concrete slabs and next to two corpses in a garment factory that collapsed Wednesday in Savar, near Dhaka, Bangladesh, Thursday, April 25, 2013. Deep cracks visible in the walls of the Bangladesh garment building had compelled police to order it evacuated a day before it collapsed, officials said Thursday. More than 200 people were killed when the eight-story building splintered into a pile of concrete because factories based there ignored the order and kept more than 2,000 people working. (AP Photo/AP video)

In this image taken from AP video, garment worker Mohammad Altab moans to rescuers for help while trapped between concrete slabs and next to two corpses in a garment factory that collapsed Wednesday in Savar, near Dhaka, Bangladesh, Thursday, April 25, 2013. Deep cracks visible in the walls of the Bangladesh garment building had compelled police to order it evacuated a day before it collapsed, officials said Thursday. More than 200 people were killed when the eight-story building splintered into a pile of concrete because factories based there ignored the order and kept more than 2,000 people working. (AP Photo/AP video)

Bangladeshi people gather as rescuers look for survivors and victims at the site of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete. (AP Photo/A.M.Ahad)

Relatives cry as rescuers look for survivors and victims at the site of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete on Wednesday. (AP Photo/A.M.Ahad)

Bangladesh rescuers look for survivors and victims at the site of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete. (AP Photo/A.M.Ahad)

A Bangladeshi rescuer looking for survivors emerges from beneath a concrete slab of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete on Wednesday. (AP Photo/A.M.Ahad)

(AP) ? "Save us, brother. I beg you, brother," Mohammad Altab moaned to the rescuers who could not help him. He had been trapped for more than 24 hours, pinned between slabs of concrete in the ruins of the garment factory building where he worked.

"I want to live," he pleaded, his eyes glistening with tears as he spoke of his two young children. "It's so painful here."

Altab should not have been in the building when it collapsed Wednesday, killing at least 238 people.

No one should have.

After seeing deep cracks in the walls of the building on Tuesday, police had ordered it evacuated. But officials at the garment factories operating inside ignored the order and kept more than 2,000 people working, authorities said.

The disaster in Savar, an industrial suburb of Dhaka, the capital city, is the worst ever for Bangladesh's booming and powerful garment industry, surpassing a fire five months ago that killed 112 people and brought widespread pledges to improve the country's worker-safety standards.

Instead, very little has changed in Bangladesh, where wages, among the lowest in the world, have made it a magnet for numerous global brands. Companies operating in the collapsed building say their customers included retail giants such as Wal-Mart, Dress Barn and Britain's Primark.

On Thursday, hundreds of rescuers, some crawling through the maze of rubble in search of survivors and corpses, spent a second day working amid the cries of the trapped and the wails of workers' relatives gathered outside the Rana Plaza building, which housed numerous garment factories and a handful of other companies.

Rescuers on Thursday evening found 40 survivors trapped in a room on the fourth floor. Twelve were soon freed, and crews worked to get the others out safely, said Brig. Gen. Mohammed Siddiqul Alam Shikder, who is overseeing rescue operations. Crowds at the scene burst into applause as survivors were brought out, although no other details were immediately available.

An Associated Press cameraman who went into the rubble Thursday morning with rescue workers spoke briefly to Atlab, the man who pleaded to be saved. But the team was unable to free Atlab, who was trapped next to two corpses.

From deep inside the rubble, another survivor could be heard weeping as he called for help.

"We want to live, brother! It's hard to remain alive here. It would have been better to die than enduring such pain to live on. We want to live! Please save us," the man cried. It was not immediately clear if he or Atlab were among those later rescued.

After the cracks were reported, managers of a bank that had an office in the building evacuated their employees. The garment factories, though, kept working, ignoring the instructions of the local industrial police, said Mostafizur Rahman, a director of that police force.

Abdur Rahim, who worked on the fifth floor, said he and his co-workers had gone inside Wednesday morning despite seeing the cracks. He said a factory manager had assured people it was safe.

About an hour later, the building collapsed, and the next thing Rahim remembered was regaining consciousness outside.

Officials said they had made it very clear that the building needed to be evacuated.

The Bangladesh Garment Manufacturers and Exporters Association had also asked the factories to suspend their work.

"After we got the crack reports, we asked them to suspend work until further examination, but they did not pay heed," said Atiqul Islam, the group's president.

As crews bored deeper into the wreckage, the odor of decaying bodies wafted through the building. Bangladesh's junior minister for home affairs, Shamsul Haque, said 2,000 people had been rescued.

Maj. Gen. Chowdhury Hasan Suhrawardy, a top military officer in the Savar area, told reporters that search and rescue operations would continue for at least three days after the collapse.

"We know a human being can survive for up to 72 hours in this situation. So our efforts will continue non-stop," he said.

Meanwhile, thousands of workers from the hundreds of garment factories across the Savar industrial zone took to the streets to protest the collapse and poor safety standards.

Shikder said the death toll had reached 238 by Thursday night. The garment manufacturers' group said the factories in the building employed 3,122 workers, but it was not clear how many were inside it when it collapsed.

Dozens of bodies, their faces covered, were laid outside a school building so relatives could identify them. Thousands gathered outside the building, waiting for news. TV reports said hundreds of protesters clashed with police in Dhaka and the nearby industrial zone of Ashulia. It was not immediately clear if there were any injuries in those clashes.

After the November fire at the Tazreen Fashions Ltd. factory, there were repeated calls for improved safety standards by labor activists, manufacturers, the government and major retailers, but little progress.

The building collapse highlighted the dangers that workers still face. Bangladesh has about 4,000 garment factories and exports clothes to leading Western retailers, and industry leaders hold great influence in the South Asian nation.

Its garment industry was the third largest in the world in 2011, after China and Italy. It has grown rapidly in the past decade, a boom fueled by Bangladesh's exceptionally low labor costs. The country's minimum wage is now the equivalent of about $38 a month.

Officials said soon after the collapse that numerous construction regulations had been violated.

Abdul Halim, an official with Savar's engineering department, said the owner of Rana Plaza was originally allowed to construct a five-story building but added another three stories illegally.

On a visit to the site, Home Minister Muhiuddin Khan Alamgir told reporters the building had violated construction codes and that "the culprits would be punished." Local police chief Mohammed Asaduzzaman said police and the government's Capital Development Authority have filed separate cases of negligence against the building's owner.

But on the streets of Dhaka, many believe the owners of the building and the factories will ultimately walk free.

"Was anyone punished earlier? Was the owner of Tazreen Fashions arrested? They are powerful people, they run the country," said Farid Ahmed, an insurance company official.

The Tazreen factory that burned in November lacked emergency exits, and its owner said only three floors of the eight-story building were legally built. Surviving employees said gates had been locked and managers had told them to go back to work after the fire alarm sounded.

Habibur Rahman, police superintendent of the Dhaka district, identified the owner of the collapsed building as Mohammed Sohel Rana, a local leader of ruling Awami League's youth front. Rahman said police were also looking for the owners of the garment factories.

Among the garment makers in the building were Phantom Apparels, Phantom Tac, Ether Tex, New Wave Style and New Wave Bottoms. Altogether, they produced several million shirts, pants and other garments a year.

The New Wave companies, according to their website, make clothing for major brands including North American retailers The Children's Place and Dress Barn, Britain's Primark, Spain's Mango and Italy's Benetton. Ether Tex said Wal-Mart, the world's biggest retailer, was one of its customers.

The Cato Corporation, which sells moderately-priced women's and girls' clothing, said that New Wave Bottoms was one of its vendors, but that it had no production with them at the time of the collapse.

Primark acknowledged it was using a factory in Rana Plaza, but many other retailers distanced themselves from the disaster, saying they were not involved with the factories at the time of the collapse or had not recently ordered garments from them.

Benetton said in an email to the AP that people involved in the collapse were not Benetton suppliers. Wal-Mart said it was investigating, and Mango said it had only discussed production of a test sample of clothing with one of the factories.

Highlighting failings in the patchwork system that retailers use to audit factories, two of Rana Plaza's garment companies had passed inspections by a major European group that does factory audits in developing countries. But the Business Social Compliance Initiative, which represents hundreds of companies and audited the Phantom Apparels and New Wave Style factories, said its standards focus more on labor issues than building standards.

___

Associated Press Writers Muneeza Naqvi and Tim Sullivan in New Delhi, Stephen Wright in Bangkok, and Kay Johnson in Mumbai contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-25-Bangladesh-Building%20Collapse/id-d76be53c2a33483a83962fb84db90a54

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Social networks are getting political, but it's no revolution, says Pew ...

"Liking" a post by the president or a human rights group may not be the most powerful form of political expression, but according to a recent Pew Research Center study, it is at least something that a person of nearly any age, location or economic status can do ? and does.

The study shows that social networks have become a very popular platform for political involvement. But it's not quite a shining new world of online activism just yet: Under close scrutiny, the groups and divides that have traditionally defined political action are still quite present.

According to Pew's Internet & American Life Projectphone survey of 2,235 American adults, 39 percent took part in "political activities" on social networks during the 2012 election season, up from 26 percent in 2008. And these link-posting, politician-friending, issue-discussing users are more likely to engage with the political process in other ways, as well, from volunteering to addressing community problems.

And interestingly, when it comes to talking politics on social networks, it doesn't seem to matter nearly as much whether you're young or old, rich or poor. The difference in engagement between those groups, usually very pronounced, was far less so among users of social media. For instance, those on social networks who earned under $10,000 had the same level of political involvement as those earning over $150,000.

But if you look a little closer, some patterns re-emerge. Aaron Smith, the study's author, explained: "If you look at education instead of income, you see the same long-standing pattern where the college-educated are especially likely to use these sites for political purposes."

As soon as you step back and look at the whole U.S. adult population, social media just appears as a tool for those who are already engaged in offline political activities, says Pew. "These new channels do not appear to be altering the fundamental pattern that the well-educated and financially well-off are more likely to participate in civic life."

What's more, offline political conversation is still dominant, despite the social media buzz. "On an 'every day' level, Americans are three times as likely to discuss politics or public affairs with others through offline channels (such as talking in person or over the telephone) as they are through online channels," said Pew Research, in a press release.

Some have argued that President Obama owes his reelection at least partially to the massive efforts at growing the campaign's online presence, especially on social media. But does this engagement really have an effect on election outcomes? A previous Pew study showed that nearly a quarter of registered voters told friends and followers who they voted for but, as it happens, most of those people associated primarily in like-thinking groups.

In fact, yet another Pew report says that 9 percent of social network users "have blocked, unfriended or hidden someone on the site because they posted something about politics or issues that they disagreed with or found offensive."

It may take some time for social media to evolve into more of a forum for earnest political discussion and the exchange of ideas.

Devin Coldewey is a contributing writer for NBC News Digital. His personal website is coldewey.cc.

Source: http://www.nbcnews.com/technology/technolog/social-networks-are-getting-political-its-no-revolution-says-pew-6C9585954

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Bangladesh building tragedy down to West's cost squeeze: NGOs

LONDON (Reuters) - Major western clothing retailers squeezing Asian suppliers and a flawed approach to ensuring even basic working standards are fuelling conditions for tragedies like the latest factory collapse in Bangladesh, NGOs said on Thursday.

At least 260 people, mainly female workers, were killed and more than 1,000 were injured when the eight-storey Rana Plaza factory building in Savar, 30 km (20 miles) outside the capital Dhaka, collapsed on Wednesday.

"What we're saying is that bargain-basement (clothing) is automatically leading towards these types of disasters," John Hilary, executive director at British charity War on Want, told Reuters.

He said western clothing retailers' desire to undercut rivals has translated into increasing pressure on foreign suppliers to reduce costs.

"If you've got that, then it's absolutely clear that you're not going to be able to have the right kind of building regulations, health and safety, fire safety. Those things will become more and more impossible as the cost price goes down."

Hilary said the push for lower costs inevitably led to factories cutting corners. "As a result of that, we see the sort of disaster that happened yesterday," he said.

War on Want and its partner in Bangladesh, the National Garment Workers' Federation, called on major international buyers to be held to account.

"This negligence must stop. The deaths of these workers could have been avoided if multinational corporations, governments and factory owners took workers' protection seriously," NGWF president, Amirul Haque Amin, said in a statement.

Gareth Price-Jones, Bangladesh country director of British charity Oxfam, said western companies had not done enough.

"Western buyers could be doing much, much more, and they have a moral responsibility to do so," he told Reuters. "Western buyers really need to press for decent wages and safe working conditions."

He said Bangladeshi building regulations were not robust enough for construction in an earthquake zone and were, in any case, frequently ignored.

Around 4,500 Bangladeshi factories produce clothes for many of the world's major brands, employing 4 million workers and generating 80 percent of Bangladesh's $24 billion annual exports, making it the world's No. 2 apparel exporter behind China.

People watch as rescue workers continue their operations at the collapsed Rana Plaza building in Savar, 30 km (19 miles) outside Dhaka April 25, 2013. Survivors from the garment factory that collapsed... more? People watch as rescue workers continue their operations at the collapsed Rana Plaza building in Savar, 30 km (19 miles) outside Dhaka April 25, 2013. Survivors from the garment factory that collapsed in Bangladesh killing at least 228 people described on Thursday a deafening bang and tremors before the eight-floor building crashed down under them. REUTERS/Stringer (BANGLADESH - Tags: BUSINESS DISASTER TPX IMAGES OF THE DAY) less? But with wages as low as $37 a month for some workers toiling for 10-15 hours a day, and increasing publicity about unsanitary and unsafe working conditions, some retailers were getting worried about their reputation.

AUDITS QUESTIONED

A lot have introduced corporate social responsibility (CSR) programs, where they carry out factory audits and inspections and talk to employees about worker conditions.

But War on Want says the CSR processes are often flawed.

"What happens is the workers are trained in what to say, the factories present favorable books and keep back the real books," Hilary said, noting that in countries like China there were courses to coach factories on how to pass an audit without telling the truth.

The Savar disaster came five months after Bangladesh's worst factory fire, which killed 112 people, and another incident at a factory in January in which seven died.

The Ethical Trading Initiative, an umbrella organization that brings NGOs, unions and brands together to try to improve working conditions, said the latest tragedy demonstrated the chronic widespread problems in the sector that affect the most basic of workers' rights.

"These incidents all serve as yet another call to action for the Bangladesh industry, government, retailers, worker representatives and NGOs to work together, to raise workplace safety standards across the country's garment sector," it said.

In Washington, the Asia advocate for the U.S. NGO Human Rights Watch said weak protection of labor rights contributed to the tragedy at Rana Plaza, where none of the factories are unionized.

"Had one or more of the Rana Plaza factories been unionized, its workers would have been in a position to refuse to enter the building on Wednesday morning," said John Sifton.

"The right to organize a union in Bangladesh is not just a matter of getting fair wages, it's a matter of saving lives," he said.

U.S. State Department deputy spokesman Patrick Ventrell told reporters that labor rights in Bangladesh, as well as work conditions, were "something that we've raised in the human rights report, we raised in our bilateral dialogue, certainly directly with the government from our embassy."

The State Department's annual human rights report for 2012, published on April 19, said trade unions in Bangladesh were able to conduct collective bargaining, "but government action made it nearly impossible to form new trade unions in many sectors, for example, in the ready-made garment and shrimp industries."

(Reporting by James Davey, Neil Maidment, and Paul Eckert in Washington; Editing by Will Waterman and Mohammad Zargham)

Source: http://news.yahoo.com/death-toll-bangladesh-building-collapse-rises-147-015232779.html

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Insert Coin: Lightpack turns your computer display into an ambient backlight (video)

Insert Coin Lightpack turns any display into an ambient backlight

While Philips did eventually bring its Ambilight technology to PC monitors, it wasn't before others had decided to roll their own. Now you can add ambient backlighting to any computer display without any of the attendant soldering and Arduino-wrangling, thanks to the folks at Woodenshark. The team has built Lightpack, an Ambilight-esque system that'll connect to a Windows, OS X or Linux PC and project the display's colors onto the area surrounding the screen.

Plug the hockey puck-sized device into your computer, attach 10 LED modules to the back of your display and install the open-source software and you're good to go. Once ready, you can even set up custom alerts to measure CPU temperature or email volumes, and even control the lighting with your smartphone or tablet. The team has asked for the unusually specific figure of $261,962 in order to fund an initial production run of 5,000 units, with early backers able to snag one of the units for $50 instead of around $90. Interested to watch it in action? There's a video after the break, friends.

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Source: Kickstarter

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/KJJ-k3LM98U/

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Mammal and bug food co-op in the High Arctic

Apr. 24, 2013 ? Who would have thought that two very different species, a small insect and a furry alpine mammal, would develop a shared food arrangement in the far North?

University of Alberta researchers were certainly surprised when they discovered the unusual response of pikas to patches of vegetation that had previously been grazed on by caterpillars from a species normally found in the high Arctic.

U of A biology researcher Isabel C. Barrio analyzed how two herbivores, caterpillars and pikas, competed for scarce vegetation in alpine areas of the southwest Yukon. The caterpillars come out of their winter cocoons and start consuming vegetation soon after the snow melts in June. Weeks later, the pika starts gathering and storing food in its winter den. For the experiment, Barrio altered the numbers of caterpillars grazing on small plots of land surrounding pika dens.

"What we found was that the pikas preferred the patches first grazed on by caterpillars," said Barrio. "We think the caterpillar's waste acted as a natural fertilizer, making the vegetation richer and more attractive to the pika."

U of A biology professor David Hik, who supervised the research, says the results are the opposite of what the team expected to find.

"Normally you'd expect that increased grazing by the caterpillars would have a negative effect on the pika," said Hik. "But the very territorial little pika actually preferred the vegetation first consumed by the caterpillars."

The researchers say it's highly unusual that two distant herbivore species -- an insect in its larval stage and a mammal -- react positively to one another when it comes to the all-consuming survival issue of finding food.

These caterpillars stay in their crawling larval stage for up to 14 years, sheltering in a cocoon during the long winters before finally becoming Arctic woolly bear moths for the final 24 hours of their lives.

The pika does not hibernate and gathers a food supply in its den. Its food-gathering territory surrounds the den and covers an area of around 700 square metres.

The researchers say they'll continue their work on the caterpillar-pika relationship to explore the long-term implications for increased insect populations and competition for scarce food resources in northern mountain environments.

Barrio was the lead author on the collaborative research project, which was published April 24 in the journal Biology Letters.

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Story Source:

The above story is reprinted from materials provided by University of Alberta, via EurekAlert!, a service of AAAS. The original article was written by Brian Murphy.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. I. C. Barrio, D. S. Hik, K. Peck, C. G. Bueno. After the frass: foraging pikas select patches previously grazed by caterpillars. Biology Letters, 2013; 9 (3): 20130090 DOI: 10.1098/rsbl.2013.0090

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/apG4-pzYpt8/130424161114.htm

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Longer days bring 'winter blues' -- for rats, not humans

Apr. 25, 2013 ? Most of us are familiar with the "winter blues," the depression-like symptoms known as "seasonal affective disorder," or SAD, that occurs when the shorter days of winter limit our exposure to natural light and make us more lethargic, irritable and anxious. But for rats it's just the opposite.

Biologists at UC San Diego have found that rats experience more anxiety and depression when the days grow longer. More importantly, they discovered that the rat's brain cells adopt a new chemical code when subjected to large changes in the day and night cycle, flipping a switch to allow an entirely different neurotransmitter to stimulate the same part of the brain.

Their surprising discovery, detailed in the April 26 issue of Science, demonstrates that the adult mammalian brain is much more malleable than was once thought by neurobiologists. Because rat brains are very similar to human brains, their finding also provides a greater insight into the behavioral changes in our brain linked to light reception. And it opens the door for new ways to treat brain disorders such as Parkinson's, caused by the death of dopamine-generating cells in the brain.

The neuroscientists discovered that rats exposed for one week to 19 hours of darkness and five hours of light every day had more nerve cells making dopamine, which made them less stressed and anxious when measured using standardized behavioral tests. Meanwhile, rats exposed for a week with the reverse -- 19 hours of light and five hours of darkness -- had more neurons synthesizing the neurotransmitter somatostatin, making them more stressed and anxious.

"We're diurnal and rats are nocturnal," said Nicholas Spitzer, a professor of biology at UC San Diego and director of the Kavli Institute for Brain and Mind. "So for a rat, it's the longer days that produce stress, while for us it's the longer nights that create stress."

Because rats explore and search for food at night, while humans evolved as creatures who hunt and forage during the daylight hours, such differences in brain chemistry and behavior make sense. Evolutionary changes presumably favored humans who were more active gatherers of food during the longer days of summer and saved their energy during the shorter days of winter.

"Light is what wakes us up and if we feel depressed we go for a walk outside," said Davide Dulcis, a research scientist in Spitzer's laboratory and the first author of the study. "When it's spring, I feel more motivation to do the things I like to do because the days are longer. But for the rat, it's just the opposite. Because rats are nocturnal, they're less stressed at night, which is good because that's when they can spend more time foraging or eating."

But how did our brains change when humans evolved millions of years ago from small nocturnal rodents to diurnal creatures to accommodate those behavioral changes?

"We think that somewhere in the brain there's been a change," said Spitzer. "Sometime in the evolution from rat to human there's been an evolutionary adjustment of circuitry to allow switching of neurotransmitters in the opposite direction in response to the same exposure to a balance of light and dark."

A study published earlier this month in the American Journal of Preventive Medicine found some correlation to the light-dark cycle in rats and stress in humans, at least when it comes to people searching on the internet for information in the winter versus the summer about mental illness. Using Google's search data from 2006 to 2010, a team of researchers led by John Ayers of San Diego State University found that mental health searches on Google were, in general, 14 percent higher in the winter in the United States and 11 percent higher in the Australian winter.

"Now that we know that day length can switch transmitters and change behavior, there may be a connection," said Spitzer.

In their rat experiments, the UC San Diego neuroscientists found that the switch in transmitter synthesis in the rat's brain cells from dopamine to somatostatin or back again was not due to the growth of new neurons, but to the ability of the same neurons there to produce different neurotransmitters.

Rats exposed to 19 hours of darkness every 24 hours during the week showed higher numbers of dopamine neurons within their brains and were more likely, the researchers found, to explore the open end of an elevated maze, a behavioral test showing they were less anxious. These rats were also more willing to swim, another laboratory test that showed they were less stressed.

"Because rats are nocturnal animals, they like to explore during the night and dopamine is a key part of our and their reward system," said Spitzer. "It's part of what allows them to be confident and reduce anxiety."

The researchers said they don't know precisely how this neurotransmitter switch works. Nor do they know what proportion of light and darkness or stress triggers this switch in brain chemistry. "Is it 50-50? Or 80 percent light versus dark and 20 percent stress? We don't know," added Spitzer. "If we just stressed the animal and didn't change their photoperiod, would that lead to changes in transmitter identity? We don't know, but those are all doable experiments."

But as they learn more about this trigger mechanism, they said one promising avenue for human application might be to use this neurotransmitter switch to deliver dopamine effectively to parts of the brain that no longer receive dopamine in Parkinson's patients.

"We could switch to a parallel pathway to put dopamine where it's needed with fewer side effects than pharmacological agents," said Dulcis.

The other researchers involved in the study, which was funded by grants from the Ellison Medical Foundation, were Pouya Jamshidi and Stefan Leutgeb of UC San Diego.

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Story Source:

The above story is reprinted from materials provided by University of California - San Diego.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. D. Dulcis, P. Jamshidi, S. Leutgeb, N. C. Spitzer. Neurotransmitter Switching in the Adult Brain Regulates Behavior. Science, 2013; 340 (6131): 449 DOI: 10.1126/science.1234152

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/jWxZHMiyj5c/130425142430.htm

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